BDBM50246253 4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine::AZD-5438::CHEMBL488436

SMILES CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(cc2)S(C)(=O)=O)n1

InChI Key InChIKey=WJRRGYBTGDJBFX-UHFFFAOYSA-N

Data  14 IC50  1 Kd

PDB links: 5 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50246253   

TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

LigandBDBM50246253(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(me...)Copy SMILESCopy InChI

Affinity DataIC50:  450nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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